Meet Aubrai and His $100K Hypothesis Challenge for Longevity Research
AUBRAI is an on-chain AI agent accelerating longevity research. Built with Dr. Aubrey de Grey's expertise, it synthesizes papers, critiques study designs, and shares live updates about RMR2.
At the heart of AUBRAI's mission lies the Robust Mouse Rejuvenation (RMR2) project - an ambitious study to double the remaining lifespan of middle-aged mice. If successful, it could be aging's 'AlphaFold moment': a proof that multi-target rejuvenation works and is worth scaling.
The $100K Hypothesis Challenge
Calling all researchers!
► Use @Aubrai_ to create and refine a longevity hypothesis
► Best hypotheses are selected by @aubreydegrey and qualify for up to $100K in funding
► 20K $BIO bounty for referring researchers whose hypotheses get selected
How it works
• Researchers worldwide can use Aubrai as a researcher co-pilot to fine-tune novel hypotheses about longevity - eg, a new clinical treatment or biological mechanism.
• Submit a research proposal in the form below
• Aubrey de Grey will select the top hypotheses, making them eligible for up to $100K in milestone-based research funding.
• Funding comes from IP-Token “Ignition Sales” on the Bio Launchpad & VitaLabs, VitaDAO’s incubation program for scientists pioneering high-risk, high-reward longevity research, turning ideas into IPTs and biotech spinouts through a community-driven funding model.
$BIO Bounty
Know someone who might be interested in submitting a research proposal? They could be students, medical professionals or independent researchers.
Submit research proposal here.
VItaDAO developed Aubrai with the help of Bio Protocol. Aubrai is trained on the unpublished lab data of longevity scientist Aubrey de Grey as well as knowledge collected from researchers worldwide via social media, messaging platforms and the Aubrai terminal.
As an onchain AI co-scientist, Aubrai can generate and validate hypotheses, design wet-lab experiments and encrypt scientific data, enriching research outputs while protecting trade secrets.
AI-driven biology is experiencing explosive growth, with giants like Google and OpenAI building scientific agents capable of reading papers and generating hypotheses. But these tools remain siloed in Web2 - disconnected from capital, coordination and shared knowledge. Aubrai breaks these barriers by integrating scientific AI with onchain features for data sharing, continuous funding and discovery monetization, directly engaging the global longevity community.
How to Use Aubrai
- You can now prompt Aubrai on X by tagging @Aubrai_. The agent is designed to answer a range of questions - from complex scientific inquiries to general health hacks.
- Valid hypotheses generated by Aubrai are hashed on Base through Molecule's Proof-of-Invention (POI). This creates a blockchain-verified trail of scientific progress, enabling value and recognition from breakthroughs to flow upstream to contributors whose early insights or negative results paved the way for later discoveries.
- View the Aubrai dashboard for tracking hypotheses generated, knowledge ingested, IP-NFTs and other agent analytics. The Aubrai Researcher Terminal is currently in Private Beta, with verified researchers including those with .edu emails getting expedited access. Sign up for Beta access.
Aubrai can utilize funding from $AUBRAI trading fees to bootstrap experiments, and eventually tokenize validated data as onchain knowledge assets known as IP-Tokens.

RMR2 Study
Aubrai is trained on cutting-edge research from Dr. de Grey’s lab, LEV Foundation, including the Robust Mouse Rejuvenation (RMR2) project, a comprehensive study testing rejuvenation therapy combinations to achieve lifespan extension in mice. If successful, it could be aging's "AlphaFold moment": a proof that multi‑target rejuvenation works and is worth scaling.
Findings from the RMR2 study will be fed directly into Aubrai’s knowledge graph, continuously enriching the agent with the latest insights from LEV.

Scaling Longevity Intelligence
Dr. Aubrey de Grey said: “Aubrai represents a radical new way to scale collective scientific intelligence. By fusing my team’s expertise with decentralized AI and the wisdom of the global longevity community, we're creating something unprecedented – a scientific AI agent that doesn't just process information, but actively helps researchers turn discoveries into real-world therapeutics.”
The $AUBRAI Token
Aubrai Contract Address: 0x9d56c29e820Dd13b0580B185d0e0Dc301d27581d
Aubrai on Aerodrome
Aubrai on Coingecko:
Aubrai twitter/x @Aubrai_:
Aubrai on Coindesk: https://www.coindesk.com/markets/2025/08/25/decentralized-science-project-aubrai-launches-on-base-to-tackle-science-funding-s-valley-of-death
Aubrai Website: https://aubr.ai/
Learn more about Aubrai: https://docs.aubr.ai/
