Stage: Early Stage Preclinical Discovery
Area: Drug Repurposing
Status: Ongoing
Patent: Not Filed Yet
The study, consisting of over 1.4 billion prescriptions, found that a number of prescription drugs were highly associated with longer life- and health-span in long-live populations. Here, we present a unique investment opportunity. We seek to validate these observations through a series of carefully conducted wet lab experiments. If successful, this work could result in the repurposing of several FDA-approved therapeutics for the purpose of extending human lifespan, at a lower cost and over faster timelines than conceivably possible with de novo drug discovery. This unique investment opportunity allows savvy longevity investors the chance to own a share of the potential intellectual property generated from these studies, and in turn, a potential share in the future of life extension.
The global elderly population is projected to substantially increase throughout the 21st century. By the year 2100 a fifth of the total world population will be aged 65 or older posing a serious socioeconomic challenge to societies world-wide. Interventions that ensure healthy aging are therefore of critical importance.
Pre-Clinical Studies 1: Testing in Fruit Flies and Human Cells
Required Funding: $500,000
Status: Ongoing
Duration: 24 Months
Testing the identified drugs ability to attenuate features of aging in a controlled laboratory setting. Here, we will test the molecules in human cells and in the animal model drosophila melanogaster (fruit flies). We are testing the drugs in human cells to rapidly understand how the molecules affect human cellular aging. Fruit flies are used extensively in biomedical research and particular aging research as they have a short lifespan of about 60 days.
This program focuses on testing and developing three of these small molecules as possible interventions in aging. Specifically, we will test the drugs on human cell cultures and in various animal models. Importantly, the current anti-aging market stands at 200 billion USD, even without a single scientifically proven treatment. Our molecules targets this specific market with the aim of letting everyone live healthier, happier and longer lives.
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The vote has passed, the decision is made: Morten Scheibye-Knudsen Lab will be the first research organisation to fund their longevity research via an IPNFT. This historic moment needs to be celebrated properly!
Lab-Tour with Founder Morten
Take a quick look at Scheibye-Knudsen Lab in Copenhagen, where the first longevity research project to be funded by VitaDAO is prepared.
The Flies are ready! Scheibye-Knudsen Lab Update
A first intro by the team of The Scheibye-Knudsen Lab, one of the first research project getting funded by VitaDAO.
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Senescent cells accumulate with age and are associated with numerous diseases. Dr. Amit Sharma’s team have identified senescence-specific cell surface biomarkers which will act as targets for developing Chimeric Antigen Receptor Natural Killer (CAR-NK) cells aiming to precisely and safely eliminate senescent cells in vivo.
Mitophagy - the mechanism to recycle mitochondria - becomes dysregulated with age and is thought to be a driver of Alzheimer’s and other age-related diseases. The Fang lab aims to use a combination of artificial intelligence and a wet-lab validation platform to identify new mitophagy-activating drug candidates.
Turn Bio develops mRNA medicines that induce the body to heal itself by instructing specific cells to fight disease or repair damaged tissue. They are reprogramming the epigenome – a network of chemical compounds and proteins controlling cell functions to restore capabilities that are lost with age.
Rubedo is building a platform for longevity medicines using “smart drugs” (prodrugs) that have the capacity to selectively be activated in target cells predicted to be pathogenic and the cause of age-related diseases.
